Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases

Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52. doi: 10.1016/s0960-894x(99)00210-3.

Abstract

A new class of protein kinase bisubstrate-analog inhibitors was designed on the basis of adenosine-5'-carboxylic acid derivatives, where a short peptide was attached to the 5'-carbon atom of the adenosine sugar moiety via a linker chain. The potency and selectivity of these inhibitors were adjusted by relevant combination of these structural fragments, resembling the structure of the bisubstrate complex of the peptide phosphorylation reaction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine / chemistry*
  • Carboxylic Acids / chemistry
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Molecular Structure
  • Peptides / chemical synthesis*
  • Peptides / chemistry
  • Peptides / pharmacology
  • Protein Kinase Inhibitors*

Substances

  • Carboxylic Acids
  • Enzyme Inhibitors
  • Peptides
  • Protein Kinase Inhibitors
  • Adenosine